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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
1 mg	3-5days	￥866.00	登錄后可見	- +
5 mg	3-5days	￥2366.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

1 mg

3-5days

￥866.00

登錄后可見

- +

5 mg

3-5days

￥2366.00

登錄后可見

- +

基本信息

英文名稱	Inavolisib \| GDC-0077 \| RG6114 \| RO-7113755
中文名稱	Inavolisib \| GDC-0077
CAS號	2060571-02-8
分子式	C18H19F2N5O4
分子量	407.37
外觀	White to yellow powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC₅₀=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα.

相關(guān)文獻(xiàn)

Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies.

https://doi.org/10.1158/1538-7445.SABCS17-PD4-14

PMID: 36455032 DOI: 10.1021/acs.jmedchem.2c01422

PMID: 34544753 PMCID: PMC9762331 DOI: 10.1158/2159-8290.CD-21-0072

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瀏覽記錄

CL1233

Inavolisib | GDC-0077

2060571-02-8 98+% 3-5days

￥866.00 1 mg

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Inavolisib | GDC-0077

Inavolisib | GDC-0077 | RG6114 | RO-7113755

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