英文名稱 | Niraparib (MK-4827) |
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中文名稱 | 尼拉帕尼 |
CAS號(hào) | 1038915-60-4 |
分子式 | C??H??N?O |
分子量 | 320.39 |
外觀 | White to light yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
---|---|---|---|---|---|
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英文名稱 | Niraparib (MK-4827) |
---|---|
中文名稱 | 尼拉帕尼 |
CAS號(hào) | 1038915-60-4 |
分子式 | C??H??N?O |
分子量 | 320.39 |
外觀 | White to light yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer.