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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
1 mg	In-stock	￥166.00	登錄后可見	- +
5 mg	In-stock	￥366.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

1 mg

In-stock

￥166.00

登錄后可見

- +

5 mg

In-stock

￥366.00

登錄后可見

- +

基本信息

英文名稱	Brigatinib \| AP-26113
中文名稱	布格替尼
CAS號	1197953-54-0
分子式	C29H39ClN7O2P
分子量	584.09
外觀	White to light yellow powder
儲存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產(chǎn)品詳情

Brigatinib is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.

相關(guān)文獻

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models.

PMID: 27780853 DOI: 10.1158/1078-0432.CCR-16-0569

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice.

PMID: 27049722 PMCID: PMC5045374 DOI: 10.18632/oncotarget.8508

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.

PMID: 27144831 DOI: 10.1021/acs.jmedchem.6b00306

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