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基本信息

英文名稱	LY404039 \| LY2140023
中文名稱	(1R,4S,5S,6S)-4-氨基-2-硫雜雙環(huán)[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物
CAS號	635318-11-5
分子式	C?H?NO?S
分子量	235.21
外觀	White to gray powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with K_is of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects.

相關文獻

Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).

PMID: 17204749 DOI: 10.1124/jpet.106.110809

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders.

PMID: 17384937 DOI: 10.1007/s00213-007-0758-3

An agonist at glutamate and dopamine D2 receptors, LY404039.

PMID: 22884896 DOI: 10.1016/j.neuropharm.2012.07.001

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